Early childhood is replete with debates about subject matter, with arguments arising about new emphases on mathematics taking too much time away from literacy. Science is rarely mentioned, and there is often a debate about whether preschool programs should focus on social-emotional or preacademic skills. Further, there is little research on whether an emphasis in one area necessarily means less emphasis in others, or whether they can be synergistically combined. An interdisciplinary team of like-minded early childhood researchers/developers has been funded by the National Science Foundation to develop an interdisciplinary approach to math-science-literacy learning, as well as social-emotional development, working with pre-K educators serving low-resource communities in three cities. Connect4Learning will be a new interdisciplinary preschool curriculum, built upon the careful synthesis of empirically tested math and science programs and research-based approaches to literacy/language and social-emotional development, serving early childhood educators and researchers. It connects four domains—social-emotional development, literacy, science, and mathematics—and four teams of experts from each of those domains.