As blood management programs and genotyping become increasingly common approaches, immunohematology reference laboratories (IRLs) are challenged to maintain their revenue streams while reducing operational costs and assisting hospital clients to reduce their costs as well. IRLs are also facing a workforce transition from highly-experienced serologic gurus to less experienced but very talented and more technology-savvy laboratory professionals. This session will explore ways in which IRLs can reinvent themselves to remain relevant and profitable in a world where the future of molecular immunohematology is now.