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ENDO 2011 Annual Meeting

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The Year in Endocrine Genetics for Basic Scientists

Track : BASIC

Program Code: Y5

Date: Tuesday, June 7, 2011

Time: 1:00 PM to 1:45 PM EST

Location: 210ABC

SPEAKER :

William F Crowley, MD, Massachusetts Gen Hosp
Disclosure: Nothing to disclose

William F. Crowley, Jr., MD, is a Professor of Medicine at Harvard Medical School; Director of the Harvard Medical School�s Center of Excellence in Reproductive Endocrinology, one of 12 NICHD-funded Centers of Excellence in the US; Director of Clinical Research at the Mass General Hospital (MGH), and Founder and Past Chair of the Clinical Research Forum. A recipient of an Honors Curriculum BA from Holy Cross College and MD degree from Tufts School of Medicine, Dr. Crowley trained in Internal Medicine and Endocrinology at MGH from 1969 where he has remained on the Harvard Medical School and MGH faculty since. By 1984, Dr. Crowley had developed a broad-based translational research program that led to the formation of the Reproductive Endocrine Unit of the Department of Medicine. He and his colleagues pioneered the use of GnRH analogues in humans to treat children with precocious puberty which gained FDA approval in 1984. This principle of therapy using GnRH agonist-induced pituitary desensitization is now widely used in prostate cancer, endometriosis, and uterine fibroids accounting for a >$3.5B annual pharmaceutical market. Dr. Crowley also developed pulsatile GnRH therapy to induce ovulation in infertile women and complete sexual maturation and fertility in men with isolated GnRH deficiency who presented with absent or delayed puberty. Most recently, he and his colleagues have been leaders in identifying several new genes that control human puberty and sexual maturation using genetic and molecular approaches in clinical research. They have demonstrated that mutations in these genes not only account for the rare syndromes of GnRH deficiency but play a role in the more common reproductive disorders such as hypothalamic amenorrhea. In addition to these scientific accomplishments, Dr. Crowley and his Unit have a remarkable record of training >75 young physician scientists, 2/3 of which were women, and >80% of whom remain in academic medicine. Two of these postdoctoral fellows have gone on to be elected President of the Endocrine Society and 4 have served on the Endocrine Society Council. For these accomplishments, Dr. Crowley received the General Clinical Research Center (GCRC) Annual Award for Excellence in Clinical Research from both the National Institutes of Health and the Endocrine Society�s Award for Clinical Research. Dr. Crowley was also the first male to be awarded Mentor of the Year in 2001 by Women in Endocrinology. In 2005, he received the Fred Conrad Koch Award, the Endocrine Society�s highest scientific honor and in 2007, he also received the IPSEN Foundation International Prize for Endocrine Research in 2007, the highest international endocrine research award. Dr. Crowley was named an Honorary Fellow in the Royal Society of Medicine (Ire) (1999) and served as President of the Endocrine Society (2001). Dr. Crowley is also the Founder and served as Chair of the Clinical Research Forum for the 1st 15 years of its existence. This is a leading group of�60 Academic Health Centers focusing this on building a national clinical research enterprise.�Collectively they account for >75% of the NIH's extramural research budget and are the nation's translational research engine, i.e. those centers capable of taking basic research advances and turning them into more effective and safer therapies for human illness.

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(Code: Y5)

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