Suzanne A Fuqua, MS,PHD, Baylor Coll of Med Disclosure: Nothing to Disclose
Suzanne A.W. Fuqua, PhD. The main goal of my research is to determine the role of a specific somatic mutation in the estrogen receptor, called A908G or K303R ERa, in the clinical problem of hormone resistance. We were the first to discover the mutation in breast tumors, and have determined that the mutation alters many aspects of hormone action, including binding to coregulatory proteins, enhanced stability, estrogen hypersensitivity, and resistance to both the antiestrogen tamoxifen and the aromatase inhibitor anastrazole. A major goal of my laboratory is to develop novel therapeutics to target this mutation to restore hormone sensitivity, as well as identify other novel mechanisms of resistance.