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ENDO 2011 Annual Meeting

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Presidential Plenary Lecture: Nuclear Receptor Coactivators: Masters of Physiology & Disease

Track : TRANSLATIONAL

Program Code: L1-3

Date: Saturday, June 4, 2011

Time: 8:30 AM to 9:15 AM EST

Location: Grand Ballroom

SPEAKER :

Bert W O'Malley, MD, Baylor Coll of Med
Disclosure: Nothing to Disclose

Bert W. O�Malley, M.D. My goal in this work is to define the molecular mechanisms by which SRC-3, one of the SRC-family �master genetic coregulators�, participates with GREB1 to promote and maintain terminal differentiation of the mammary cell, and to then receive hormonal signals from the environment to regulate transcription factors and extra-nuclear signaling cascades that achieve adaptation and growth responses in the fully differentiated cell. My entire career and expertise�has been�directed to elucidation of the 'molecular mechanisms of steroid hormone action. I am a recognized and pioneering expert in nuclear receptors and�in coregulator discovery biology, mechanisms of intracellular function, and the role of coactivator proteins in translational biology of diseases with genetic, reproductive, oncogenic and metabolic consequences. Since our early publications on coregulators in 1992, and our discovery of nuclear receptor coactivators (i.e., SRC-1) in 1995, we have played a leading role in describing for the SRC-family: structure/functions of the �active coactivator complexes�, regulatory posttranslational modifications, diverse intracellular compartmental functions, cell physiologies, and applications to pathologies such as cancer and metabolism. During the last grant period, we made the important discovery that SRCs are regulated at the posttranslational level by PTMs. Recently, we accumulated new exciting evidence that SRC-3 functions with GREB1 to define terminal differentiation of the mammary cell, and also, that it coordinates adult cell functions at the gene and membrane levels. These observations serve as a basis for the renewal of this grant, and should provide a deep understanding of the regulatory mechanisms in normal mammary development, as well as in neoplasias such as triple negative breast cancer.

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(Code: L1-3)

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