The role of the immune system in the pathogenesis of infertility is relatively poorly defined, but available evidence suggests that poor reproductive outcomes often are associated with immunological aberration. Although many centers in the United States offer immune function testing and treatment intended to improve outcomes in cases of unexplained infertility, IVF and recurrent miscarriage, the clinical utility of immunological testing and treatments for the management of unexplained infertility, recurrent pregnancy loss and optimization of ART outcomes remains controversial. The benefits described to patients in this market – the accuracy of many available tests and the efficacy of many available immunological therapies – remains unproven. The targeted population often consists of patients who have failed IVF or experienced multiple pregnancy losses, leaving them particularly vulnerable to suggestion and emotional appeals. A 2008 gap analysis demonstrated an inconsistency between current scientific knowledge and widespread professional practice patterns. This postgraduate course for reproductive medicine specialists and immunologists will review current evidence-based reproductive immunology. The faculty will critically review the current scientific rationale for and validity of specific reproductive immunological tests and the level of evidence that supports and refutes the use of various types of immunotherapy for specific indications.


LEARNING OBJECTIVES

At the conclusion of this course, participants should be able to:
1. Describe the scientific rationale for and validity of specific immunological tests relevant to the practice of reproductive endocrinology and infertility.
2. Describe the scientific rationale for and efficacy of specific immunological therapies relevant to the practice of reproductive endocrinology and infertility.
3. Counsel patients in a just manner regarding efficacy and risk of immunological therapy intended to prevent poor
reproductive outcomes.

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