Have you ever read a new drug review and felt like you might as well have read the package insert? You are busy and you want to know if this new product is a significant improvement or a significant expense. This presentation is a bit more opinionated than those review articles in an effort to identify valuable innovations as well as new risks that must be assessed. This speaker and topic have been a part of the program at the Summer Meeting for the preceding 15 years. An updated version is being delivered to close out the Midyear Meeting to provide a broad range of drug expertise in a concise format.