Devices and methodologies have been developed and adapted over the years to procure, isolate, process and manipulate cell based products for use in stem cell transplantation, immunotherapy, gene therapy and regenerative medicine. Instruments and technical protocols have evolved to improve efficacy and safety with conventional applications and provide novel approaches for investigational protocols. This session will review the relative strengths and weaknesses of available apheresis instruments used for blood mononuclear cell collection and marrow processing. The application of additional devices and methodologies for post-collection, offline manipulations of cell based products will also be discussed with special emphasis on quality control and regulatory implications.