The risk of hemolytic transfusion reaction (HTR) as a non-infectious complication of blood transfusion is a risk which is addressed daily in transfusion services. The risk of HTR is mitigated daily with quality serologic testing, clerical accuracy and good patient management. This conference reviews the serologic and clinical picture of hemolytic transfusion reactions. HTR will be presented from the aspect of the serology focusing on what testing is critical for the proper investigation of a HTR. To partner with the serology, HTR will be reviewed from the clinician’s perspective. The serology and clinical picture are summarized in the documentation of the HTR. This presentation will also review the reporting structure for HTR in U.S. transfusion services.

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