MODERATOR
:
SPEAKER
(S):
Gerd Blobel, MD, PhD, Professor of Pediatrics, The Children's Hospital of Philadelphia
Epigenetic Mechanisms of Erythroid Lineage Stability
Harvey Lodish, PhD, Member; Professor of Biology and Professor of Biological Engineering, Whitehead Institute for Biomedical Research; Massachusetts Institute of Technology
Regulation of hematopoiesis by noncoding RNAs: LncRNAs and miRs,
Dr. Stuart Orkin, MD, David G.Nathan Professor of Pediatrics/Chairman, Dana Farber Hospital, Harvard Medical School
Reawakening expression of fetal hemoglobin in the adult.
Description
Stem cell differentiation for blood generation depends on multiple binary decisions controlled by extrinsic signals. These extrinsic signals turn on or off genes required for cell differentiation or stem cell maintenance. In the last decade, we have gained understanding of the regulatory mechanisms that control noninherited modifications of the genome that are flexible enough to respond to extrinsic signals. These noninherited genome marks constitute the epigenome. In this session, we will learn how recent developments in our understanding of the epigenome can be translated into clinically relevant applications in stem cell therapies for blood diseases and particularly for red cell diseases.
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Describe the role of long noncoding RNA and microRNA in epigenetic regulation of gene expression profiles in stem cells and lineage fate.
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Evaluate the progress of epigenetic regulation of globin gene switching by bcl11 in erythropoiesis.
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Explain the epigenetic control of expression of transcriptional factors required for erythropoiesis.
CE Category | CE Value |
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California Clinical Laboratory Personnel |
1.5 |
California Nurse |
1.8 |
Florida Laboratory Personnel |
1.8 |
General Attendee |
1.5 |
Physician |
1.5 |
Please note: Continuing education (CE) credit is available for online offerings only. Individuals that purchase CD-ROMs will not receive CE credit for the programs they view.