Immune hemolytic anemias (IHA) may be categorized as alloimmune, autoimmune and drug-induced. This session will review key concepts for the diagnosis, classification and serology of autoimmune hemolytic anemia and drug-induced immune hemolytic anemia. Case studies will supplement the theoretical review to illustrate typical serology. Equipped with academic knowledge and serologic characteristics of these sometimes difficult-to-recognize IHAs, attendees will be able to compare and contrast autoimmune hemolytic anemia and drug-induced immune hemolytic anemia in order to expedite recognition and subsequent resolution for their patients.