The age-old addage of, "there's more than meets the eye!" applies as much to the immunohematologist as to anyone else. In a case study approach, this session will cover immunohematology investigations where the initial RBC antibody identification or clinical scenario was vastly different from the final conclusion at the end of the investigation. The cases presented here will prove that, in immunohematology, it is a benefit to keep an open mind until the very end of an investigation, since there may be a suprising or odd outcome at the end!