Session Information
AABB Annual Meeting & CTTXPO 2011
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Novel Platelet Clearance Mechanisms 
Track
:
S - Scientific
Program Code:
9218-S
Date:
Sunday, October 23, 2011
Time:
2:00 PM to 3:30 PM
PST
Location:
28 C/D
DIRECTOR
:
Karin Hoffmeister, MD
MODERATOR
:
Karin Hoffmeister, MD
SPEAKER
(S):
Elisabeth Maurer-Spurej, PhD, Chief Technology Officer, LightIntegra Technology Inc
Jamey Marth, PhD, Director and Professor, Center for Nanomedicine, Sanford-Burnham Medical Research Institute, University of California Santa Barbara
Karin Hoffmeister, MD
Description
In this session, a former HHMI investigator with focus on biological functions of protein glycosylation will present how a laboratory recently demonstrated that bacteria-derived sialidases remove sialic acid from platelets, leading to platelet clearance by hepatic asialoglycoprotein receptors (Ashwell Morell receptor), thereby mitigating the lethal coagulopathy of sepsis.
Another speaker will present a second example of desialylated platelet clearance by hepatic Ashwell Morell receptors. Removal of sialic acid from glycoproteins occurs in platelets refrigerated for >12 hours and leads to the exposure of galactose moieties and removal of platelets. Possible mechanisms for desialylation of stored platelets will be discussed. A third speaker will review quality control methods of platelets for transfusion.
This session offers Self-Assessment Module (SAM) credit. Please complete the post test to receive SAM credit.
Another speaker will present a second example of desialylated platelet clearance by hepatic Ashwell Morell receptors. Removal of sialic acid from glycoproteins occurs in platelets refrigerated for >12 hours and leads to the exposure of galactose moieties and removal of platelets. Possible mechanisms for desialylation of stored platelets will be discussed. A third speaker will review quality control methods of platelets for transfusion.
This session offers Self-Assessment Module (SAM) credit. Please complete the post test to receive SAM credit.
- Describe novel glycan-lectin mediated platelet clearance mechanisms induced by cold temperatures and by bacterial neuraminidases.
- Discuss novel methods to investigate platelet quality for transfusion and how they correlate to platelet survival.
- Discuss room temperature storage cold-storage, with specific focus on platelet deterioration, bacterial growth and possible side effects of bacterial growth on platelet clearance.
| CE Category | CE Value |
|---|---|
| California Clinical Laboratory Personnel | 1.5 |
| California Nurse | 1.8 |
| Florida Laboratory Personnel | 1.8 |
| General Attendee | 1.5 |
| Physician | 1.5 |
Please note: Continuing education (CE) credit is available for online offerings only. Individuals that purchase CD-ROMs will not receive CE credit for the programs they view.
Online Access
(Code: 9218-S)
Attendee/Member:$25 USD
Attendee/Non-Member:$40 USD
Non-Attendee/Member:$40 USD
Non-Attendee/Non-Member $50 USD - Your Price
This session is a part of:
This session is a part of:
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