The American Society for Apheresis (ASFA) categorizes diseases treated by apheresis, based upon a review of the published medical literature, into indication categories to provide those practicing apheresis medicine with guidance on the appropriate apheresis therapy. The categorization in the 2010 Special Edition of the Journal of Clinical Apheresis incorporates many new changes designed to provide the apheresis practitioner even more guidance. In the newest categorizations, the category definitions have changed and a recommendation grade has been incorporated. In addition, the categorization of many diseases has changed based upon the latest available literature and new diseases not previously categorized have now been included. This session will review these changes and provide the attendee with practical knowledge on how to use the newest categorization and recommendation grade.