Session Information
AABB Audioconference Series 2011
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TRIM: Transfusion-Related Immunomodulation
Track
:
Technical/Clinical
Program Code:
114645
Date:
Wednesday, January 5, 2011
Time:
2:00 PM to 3:30 PM
EST
DIRECTOR
:
Kristina Williams, MT(ASCP)SBB, CQIA, CQA(ASQ), Senior Program Associate, Biomedical Headquarters, American Red Cross
SPEAKER
:
Sally A. Campbell-Lee, MD , Medical Director, Transfusion Medicine, University of Illinois at Chicago
Description
Transfusion related immunomodulation (TRIM) has been a controversial topic since the 1970's. TRIM previously only referred to immunosuppressant effects of transfusion, but now includes inflammatory effects. Transfusion has been observed to be associated with increased renal graft acceptance, tumor recurrence and post-operative infections. If these observations are due to TRIM, there are probably several mechanisms, which have yet to be completely elucidated.This presentation will chronologically review the previous observations of the immunomodulatory effects of transfusion, describe some proposed mechanisms and review more current data that expands the potential mechanisms which may be involved in this process.
- Describe proposed mechanisms of immunomodulatory changes seen in transfusions in animal models and surgical patients.
- Discover why transfusion related immunomodulation (TRIM) may be mediated by a variety of allogenic component attributes, including donor mononuclear cells, platelets and RBC supernatant.
- Review previous observations of the immunomodulatory effect of transfusion, including acceptance of renal allografts, increased cancer recurrence and postoperative infections.
| CE Category | CE Value |
|---|---|
| California Clinical Laboratory Personnel | 1.5 |
| California Nurse | 1.9 |
| Florida Laboratory Personnel | 1.8 |
| General Attendee | 1.5 |
| Physician | 1.5 |
Please note: Continuing education (CE) credit is available for online offerings only. Individuals that purchase CD-ROMs will not receive CE credit for the programs they view.
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