The use of apheresis technology for therapy and stem cell collections can present unique situations in pediatric patients compared to adults. The size of the patient's blood vessels compared to the size of the usual venous access device used is one example of a variable that requires special attention, particularly in small children and infants. This session consists of three lectures. The first addresses obtaining consent from parents (explaining risks and benefits) for apheresis procedures in children and obtaining assent from children old enough to understand some basic concepts. The second lecture addresses venous access and line placement issues for pediatric apheresis procedures. The third lecture addresses stem cell products and means of infusing them that present unique problems in small patients compared to adults.