MODERATOR
:
SPEAKER
(S):
Steven Spitalnik, MD, Professor, Columbia University
Mechanisms of RBC Destruction
Karina Yazdanbakhsh, PhD, Member and Head of Laboratory, New York Blood Center
Regulation of Immune Responses to Red Cell Transfusions
James Zimring, MD, PhD, Member, Puget Sound Blood Center Research Institute
Mechanisms of Resistence to Hemolysis During Crossmatch Incompatible Transfusion
Description
The humoral response to transfusion often leads to the alloimmunization of the recipient. In this session, antibody-mediated RBC hemolysis and clearance will be discussed. The speakers will review the role of T-regulatory cells in alloimmunization, discuss how the loss of antigen expression during immune-mediated RBC clearance limits the pathogenicity, outline the mechanisms of RBC destruction, and describe the pathological effects of hemolysis.
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Assess how antibody coated cells avoid antibody mediated RBC hemolysis and ex vivo sequestration.
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Describe the pathophysiological mechanisms of RBC destruction in vivo and the downstream consequences of RBC clearance from the circulation.
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Discuss what events lead to alloimmunization, and learn how T regulatory cells participate in the humoral immune response.
CE Category | CE Value |
---|
California Clinical Laboratory Personnel |
1.5 |
California Nurse |
1.8 |
Florida Laboratory Personnel |
1.8 |
General Attendee |
1.5 |
Physician |
1.5 |
Please note: Continuing education (CE) credit is available for online offerings only. Individuals that purchase CD-ROMs will not receive CE credit for the programs they view.