Applications of Phage Display to Blood Transfusion Medicine
Program Code: 218-S
Sunday, October 16, 2005
10:30 AM to 12:00 PM (ET)

MODERATOR
Don Siegel, MD, PhD, Department of Pathology, University of Pennsylvania

SPEAKERS
Don Siegel, MD, PhD, Department of Pathology, University of Pennsylvania
Eric Ostertag, MD, PhD, University of Pennsylvania
Aimee Payne, MD, PhD, Univ. of Pennsylvania, Department of Dermatology

DESCRIPTION
Phage display technology represents an extraordinarily powerful set of biological tools that facilitate the rapid and inexpensive generation of ligands, such as immunoglobulins, to a given target. Once considered a set of methods limited to the advanced molecular biology research lab, improvements in the technology have made possible its transition into the hands of both novices and big pharma enabling the routine generation of novel reagents and therapies for use in clinical settings as diverse as rheumatoid arthritis, cancer, HIV infection, obesity, and dandruff. This session will explain the basics of phage display in a simplified, straightforward manner and then present a series of examples illustrating how the display of monoclonal antibodies and other ligands such as peptides and protein functional domains can contribute enormously to transfusion medicine research and clinical practice.