Adhesion Molecules Involved in Stem Mobilization
Program Code: 108-S
Saturday, October 15, 2005
10:30 AM to 12:00 PM (ET)

MODERATOR
Leslie Silberstein, MD, Boston Children's Hospital

SPEAKERS
Neal Flomenberg, MD, Thomas Jefferson University
Hal E. Broxmeyer, PhD, Indiana University School of Medicine
Thalia Papayannopoulo, MD

DESCRIPTION
In recent years, there has been a better understanding of molecules in the bone marrow, which are critical for hematopoiesis. These molecules belong to the families known as integrins, chemokines/chemokine receptors, and bone marrow matrix carbohydrate antigens. In addition, proteases at the cell surface of hemotopoieitic cells play a role in regulating the action chemokines. The session will discuss the biology of these proteins and how they influence hematopoietic stem/progenitor homing, retention in the bone marrow and egress (mobilization) from the bone marrow.