Catalytic hydrogenation of carbon dioxide to methanol has been considered a viable pathway to reduction of greenhouse gas emissions. Methanol is regarded as a high energy density storage medium and is a precursor to a large number of chemicals and polymers. However,industrial catalysts are specifically formulated for syngas streams and are not likely optimized for CO2-rich feed gases. Under typical reaction conditions,catalyst deactivation is attributed to the loss of copper surface area,while water and side reactions (e.g.,reverse water-gas shift) can inhibit the formation of methanol. Water can competitively adsorb on the copper sites and then hinder the adsorption of CO2. Additionally, water facilitates the crystallization of the metallic copper phase and other metal oxides contained in the catalysts,thus leading to a shorter catalyst lifetime. We previously demonstrated the successful synthesis of highly active and stable copper-based catalysts using a reverse coprecipitation method under ultrasonic irradiation. In this contribution, we present the results of an investigation of multicomponent copper-based catalysts in CO2 hydrogenation to methanol at 180-260 oC and 20 bar. The addition of both gallium and yttrium in the catalysts improves the catalytic activity and stability significantly. The activity is not linearly proportional to copper surface area. It appears that metallic copper is a dominant copper species on the surface of post-reaction catalysts. The beneficial effect of Ga and Y promotion on copper sintering resistance will be discussed in detail in the presentation.